Holiday Inn Express & Suites Edwardsville is a very popular hotel in Edwardsville, with a score of 8.5 from 143 reviews. Towneplace Suites By Marriott St. Louis Edwardsville, Il (9.0 from 51 reviews) and Comfort Inn Edwardsville - St Louis (8.4 from 20 reviews) are also highly rated Edwardsville hotels based on recent feedback from HotelsCombined users.