Italy's fourth busiest airport is located just outside the town of Bergamo, around 48 kilometres north-east of Milan City Centre. Low-cost carriers primarily use Orio al Serio, and it is a rapidly expanding hub for Ryanair. Somewhat confusingly, various low-cost airlines refer to the airport as the Milan/Bergamo Airport, although this is not an official name. The airport is also known as Il Caravaggio International Airport, named after a famous baroque painter who lived in Bergamo.

Orio al Serio predominantly has domestic and European flight routes, along with a couple of connections to North Africa. Many of the flights are seasonal and only operate during the summer months. With only one terminal, it is almost exclusively a budget airline base, with operators Wizz Air and Ryanair accounting for around half of the daily flights.

The airport is located just outside the town of Bergamo and shuttle buses take just 15 minutes to reach Bergamo's train station. From here it's possible to catch a train into Milan. Various bus companies operate services to Milan City Centre and the two Milan airports. These leave at sporadic times, and it's recommended not to book in advance, as staying flexible over which bus service to take has its advantages. Bus tours are found immediately outside the station and in the terminal building, while taxis are located outside the terminal.

Michelangelo Merisi da Caravaggio was one of the pre-eminent Baroque painters and his dramatic use of lighting was highly influential in forming a style that would be taken on by artists like Rubens and Rembrandt. Reproductions of his famous artwork can be found at this airport that now bears his name.